Natsume is again meeting new youkai and helping them. A lot of friends join him along the way, he meets others who can also see the spirits and at times they join forces to solve the latest mystery. As always, Nyanko-sensei is there to help Natsume on his quests.
Natsume Takashi has the ability to see spirits, which he has long kept secret. However, once he inherits a strange book that belonged to his deceased grandmother, Reiko, he discovers the reason why spirits surround him. Containing the names of these spirits, a binding contract was formed between the spirits and the owner of the book. Now, Natsume is determined to free the spirits and dissolve the contracts. With the help of a spirit cat, his days are filled trying to return the names to these spirits.